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The accumulation of GlcCer and GlcSph may disrupt autophagy, impair mitochondria, and promote -synuclein aggregation, although a solid recognized evidence linking decreased GCase activity with substrate accumulation and -synuclein build-up is still lacking (Rocha et al., 2015)

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U-100 markings help compare syringe listings, but they should not be used to calculate or change a dose