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RA-deficient smooth muscles are hypertrophic, hypercontractile, and pro-fibrobiotic via the increased activation of the transforming growth factor beta (TGF) signaling pathway

PARP1 and PARP2 Negatively Regulate SIRT1 Activity Poly ADP-ribose polymerase (PARP) is a ribozyme that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair which consumes molecular NAD +

J Physiol Pharmacol 65:823832 Galvan DL, Green NH, Danesh FR (2017) The hallmarks of mitochondrial dysfunction in chronic kidney disease

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Novel nanocarrier systems now enable targeted delivery approachespH-responsive liposomes selectively release arginase inhibitors within acidic tumor microenvironments, while nebulized glutamine analogs achieve precise deposition at airway inflammatory sites through inhalation delivery