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Description
Using eight types of small-molecule thiol-reactive reagents as electrophilic models, we report that the selenenylsulfide bond in the non-reduced form of TrxR1 functions as a selector for the thiol-reactive reagents at pH 7.5
Platelets 21 , 393-419 (2010)
It is a strategy now used in several approved drugs (semaglutide, for example, achieves its once-weekly dosing through fatty acid-mediated albumin binding)
This method is especially popular for detoxification purposes
Strains PA14WT and PAO1WT produced about 70 and 10 M pyocyanin, respectively
