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Description
Delays in diagnosis and subsequent initiation in treatment of pernicious anaemia have been shown to increase the risk of irreversible neurological damage involving both the central and peripheral nervous system, resulting in permanent symptoms, such as peripheral neuropathy, cognitive impairment and damage to the spinal cord (known as subacute combined degeneration of the spinal cord)[9,16]

Wang et al ., 2023)

This, in turn, could influence the selection of study populations in clinical trials and improve the generalizability of findings to real-world patient cohorts

How documentation improvements support reproducibility in multi-run studies In laboratory developmental research, reproducibility depends on holding constant the variables that should not change while intentionally varying the variables under study

Interestingly, in traumatic brain injury, GPx1 deficiency was associated with decreased mitochondrial bioenergetic capacity compared to wildtype mice, whereas transgenic GPx1 mice had no decrease in mitochondrial function [114] GPx1 deficiency also enhanced apoptosis and inflammation in a cold-induced brain injury model [115]
