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Patients with certain health issues might need their doses adjusted to avoid problems

The 0.9% concentration is carefully calibrated

These patients exhibit lower numbers of retrieved oocytes, lower quality of oocytes, lower number of embryos and quality of embryos, and lower rates of blastocyst formation (118120)
The reason for persistence of desensitization in these studies when others examining the same neurons have observed greatly attenuated desensitization is not known