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Such microglial transitions likely involve epigenetic reprogramming induced by MIA, coupled with metabolic adaptations in response to subsequent stress

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However, doses above 2.4 mg showed diminishing returns due to increased gastrointestinal side effects, including nausea, vomiting, and diarrhea

Another study shows that DHA targets the TGF-Smad3 pathway to reduce hepatic fibrosis caused by a western diet (Lytle et al., 2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] 571.Rastoder E., Sivapalan P., Eklof J., Achir Alispahic I., Jordan A.S., Laursen C.B., Vestbo J., Jenkins C., Nielsen R., Bakke P., et al