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explored the regulatory effects of gut microbiota on the efficacy of Taohong Siwu Decoction (TSD) and identified a microbial metabolite that effectively inhibited DNA replication, highlighting the pivotal role of gut microbiota in determining the pharmacological outcomes of TCM ( 6.2 The effects of TCM on gut microbiota The active compounds in TCM interact with the gut microbiota directly or via metabolic conversion, selectively inhibiting or promoting the growth of specific microbial species to modulate the microbiotas structure and function ( 6.2.1 Impact on the diversity and abundance of gut microbiota The primary constituents of TCM, including alkaloids, phenolics, terpenoids, flavonoids, and organic acids, can inhibit the growth of pathogenic bacteria like Escherichia coli and Proteus while encouraging the growth of beneficial species like Lactobacillus , Bifidobacterium , and Clostridium , thereby altering the diversity and abundance of gut microbiota (Figure 3)

Adipose tissue is able to synthesize and release locally and systemically pro-inflammatory and anti-inflammatory cytokines, such as leptin but also TNF-, IL-6, adiponectin, and resistin

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New evidence suggests that ferroptosis plays a key role in the pathophysiology of the testis

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