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Endogenous VIP is released by numerous stimuli such as acetylcholine (ACh) 22 , ATP 23 , serotonin (5-HT) 24 , substance P (SP) 25 , GLP-2 26 , and xenin-25 27 from at least two populations of VIP-positive nerves: cholinergic and non-cholinergic VIP-releasing nerves

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