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Subsequently, the KFERQ-like sequence for protein targeting to lysosomes was identified (31), and it was confirmed that heat shock cognate 70 (HSC70) binds to this region, targeting substrates to lysosomes for ATP-dependent degradation, initiating research into chaperone recognition for selective lysosomal degradation (32)

doi: 10.1093/hmg/ddw260

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Sumbul-Sekerci B., Sekerci A., Pasin O., Durmus E., Yuksel-Salduz Z.I

And it's basically the premises, can we synthesize and utilize this gene to turn on the gene in humans and have us secrete and produce a higher level of this protein or this amino acid and would it drive our health span and reduce our risk of cancers

Especially, smoking is a well-established risk factor for COPD among them [82, 83]
