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Description
E1 is a thiamin pyrophosphate (TPP)-dependent -ketoacid dehydrogenase, R -lipoic acid functions as a prosthetic group essential for E2 transacetylase activity, and E3 is a flavin adenine dinucleotide (FAD)-dependent dihydrolipoamide dehydrogenase ( Figure 4 )

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Glycine Encephalopathy Deficiencies in the H, P, or T proteins of glycine decarboxylase result in glycine encephalopathy (GCE) which is characterized by nonketotic hyperglycinemia (NKH)

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