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and 2B3-102, a glutathione-PEGylated methylprednisolone liposome for acute relapses of multiple sclerosis, which completed a Phase I clinical trial in healthy volunteers

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Since Pycnogenol constituents and metabolites bound to blood cells, distribution into endothelial cells was additionally investigated (20)

For instance, mice with genetic deletion in glutamate transporter-1 exhibit reduced glutamate clearance, and consequently display abnormal cell death in motor neurons, reminiscent of amyotrophic lateral sclerosis (Staats and Van Den Bosch, 2009)

First, we tested MEPS in an ex-vivo kidney slice model, which provided a rapid and reductionist approach to assess the effect of different buffer formulations on renal tissues (32)