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In the current study, we examined early changes in the levels of oxidative stress and the expression of major presynaptic [synapsin-I, synaptophysin, growth-associated protein-43 (GAP-43), synaptosomal-associated protein-25 (SNAP-25)] and postsynaptic [drebrin, synapse-associated protein-97 (SAP-97), and postsynaptic density protein-95 (PSD-95)] proteins in hippocampal synaptosomes from IP-STZ and ICV-STZ treated rats (two different models of imparted insulin signaling)