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Organ-specific toxicity is another critical area of concern

doi:10.4067/s0034-98872017000700907

This was due to the presence of autoantibodies against folate receptor which blocked the folate binding site

These reactive compounds interact with amino groups (NH 2 ) in proteins and DNA bases, leading to the formation of adducts that can cause mutations (Yang et al., 2019)

Furthermore, structural modifications within the CNS are facilitated by central disinhibition, as demonstrated by the transformation of A nerve fibers, which typically transmit non-painful stimuli, into pain-specific secondary neurons in the dorsal horn of the spinal cord [42]