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The bone marrow of the femurs and tibias was isolated in sterile Hanks buffered salt solution (HBSS) without Ca 2+ /Mg 2+ and containing penicillin/streptomycin (1%)

mechanisms proposed include NO modulation and angiogenesis

As expected, miRNA overexpression determined a reduction in IGF1R expression and an inhibition in MEK/ERK/Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signal transduction which is involved in MMP-2 transcription regulation

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