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It is the main cause of heart attack, stroke, serious peripheral artery disease events, and cardiovascular death

Clinical Anatomy (New York, N.Y.) , 30 (7), 912921

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Sampey BP, Freemerman AJ, Zhang J, Kuan P-F, Galanko JA, OConnell TM, et al

It usually presents with pathological changes of glomerular filtration rate below 15 ml/(min1.73m^2), accompanied by retention of metabolites and toxins, and disturbance of water, electrolyte and acid-base balance as the main clinical features ( The elevated levels of TMAO in the blood of patients with ESRD have profound implications for their health status and comorbidities

James A , Page-Karjian A, Charles KE, Edwards J, Gregory CR, Cheetham S, Buter BP, Marancik DP (2021)
