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Cosmetic and Structural Changes (Ozempic Face and Muscle Loss) Rapid weight loss induced by these peptides can lead to noticeable changes in facial appearance, often colloquially referred to as Ozempic face. This is not a direct side effect of the drug itself, but rather a natural consequence of rapid subcutaneous fat loss in the face, which can lead to a hollowed, sagging, or prematurely aged appearance

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