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A Note on Rare Genetic Obesity One further drug, setmelanotide (Imcivree) , is approved by Health Canada, but only for a small group of patients with rare genetic causes of obesity (such as Bardet-Biedl syndrome)

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Repeatedly injecting in the same location can lead to lipohypertrophy, a condition characterized by lumpy, thickened areas of fatty tissue that can impair medication absorption and lead to unpredictable blood glucose levels

By mimicking the effects of endogenous GLP-1, they stimulate GLP-1 receptors, including those in cardiomyocytes and blood vessels (36)

31 It's crucial to understand that while these are common triggers and effective strategies, individual responses to foods can vary significantly