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doi: 10.1056/NEJMoa1612917
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All authors contributed to interpretation of data
The 90% confidence intervals (CIs) for the AUC and C max of warfarin in most studies were generally contained within the pre-specified 0.81.25 limits that are used to assess significance of drug-drug interactions
Tosin pointed to a few groups: people who are only slightly overweight without any weight-related medical conditions, those who aren't willing to commit to long-term treatment, and anyone whose other medical conditions would make the drugs unsafe
