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In a 104week extension among severe obesity (BMI 35), weight loss reached 30.3% (85 lbs)

ZhangQDelessaCTBakhtiARColldnMDruckerGJDet alThe glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

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Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91

doi:10.3390/ijms20235831 36