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Broad-spectrum antibiotics can temporarily reduce beneficial gut bacteria, which some research suggests play a minor role in metabolic health

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On the other hand, the brain has the ability to synthesize creatine and appears to be more resistant to the uptake of circulating creatine due to lack of expression of CRT1 in the astrocytes involved in the BBB (Beard and Braissant, 2010)

Evening injection may allow side effects to overlap with sleep, reducing awareness

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