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Intriguingly, observational studies demonstrate that patients with a higher BMI may have more severe psoriasis, and weight loss has been associated with improvements in PASI scores in patients treated with biological agents

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Patients must stay well-hydrated to offset GLP-1-related fluid loss, as testosterone-induced polycythemia can increase thrombotic risk if dehydration occurs

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In exploratory research, retatrutide represents the most ambitious incretin agent currently available

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