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This can be interpreted as the reduction of VAT after weight loss with semaglutide treatment might be related to the adipogenesis decreases and lipolysis increases to avoid more fat accumulation and improve metabolic health, which deserves further investigation

Given the paucity of evidence, there is concern whether patients on GLP-1RA are at higher risk of retained gastric contents and subsequent adverse outcomes during routine esophagogastroduodenoscopy (EGD)

By modulating macrophage polarization towards an M2 subtype, GLP-1RAs can inhibit inflammation occurring in the vessel lumen, an action which would alleviate the progression of atherosclerosis (Figure 2)

Of course, critics will counter: Sure, but drug development costs billions. Yes, drug development costs billions