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Competing interests Nik Krajnc: has participated in meetings sponsored by, received speaker honoraria or travel funding from BMS/Celgene, Janssen-Cilag, Merck, Novartis, Roche and Sanofi-Genzyme and held a grant for a Multiple Sclerosis Clinical Training Fellowship Programme from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)

Tirzepatide is sometimes referred to as the next step after GLP-1 treatments, making patients think its a GLP-2 medication

As the potential uses of these drugs expand, such as with recent approvals to prevent heart attacks and strokes in adults with cardiovascular disease who are overweight, the high cost and increased demand for these drugs may increase health spending

A vicious circle

Greater precision tends to produce more predictable pharmacologic effects, while variability can introduce uncertainty in both dosing and outcomes