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A large retrospective cohort study from Weill Cornell Medical College - examining 255 patients (92% women, mean age 64) with DXA scans before and after starting semaglutide or tirzepatide - found that GLP-1 receptor agonist use was associated with greater annualized total hip bone loss in patients without diabetes, while patients with diabetes showed bone loss more comparable to non-users

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10.2337/dc19-S009 [DOI] [PubMed] [Google Scholar] 73.Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al

She noted that patients who do not respond are often switched to different medications, and identifying likely responders in advance could help guide treatment decisions and support precision medicine

According to FDA prescribing information, nausea occurs in 1544% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported