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Description
These results suggest that GLP-1RAs regulate SREBP-2 and its downstream targets through increased AMPK and SIRT6 expression in PA-treated HepG2 cells, and that SIRT6 may partially function as an upstream regulator of AMPK
GLP 1s improve insulin resistance, blood sugar, inflammation, and blood pressure independent of weight loss

[1] [5] The mechanism of action involves several pathways that improve glycemic control and support weight loss

31 (3), 580591.e5

[10] American Journal of Managed Care
