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For the GLP-1 companion programme specifically, the evidence is more recent and still emerging

7b, EX4 stimulated insulin secretion in diabetic F344/Jcl rats
113116 Despite low potency, nonpeptidic GLP-1R agonists have been reported and showed a potential to achieve orally active GLP-1 mimetics

10.1111/jgh.13808 52 O'NeilP

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