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The JAMA Internal Medicine meta-analysis of 76 randomized trials quantified the class-wide risk: Cholelithiasis: relative risk 1.27 across all GLP-1 RAs Cholecystitis: relative risk 1.36 Biliary disease composite: relative risk 1.55 Higher doses carried higher risk than lower doses Longer treatment duration carried higher risk than shorter duration For high-risk populations, particularly older women, close monitoring for cholecystitis and cholelithiasis during GLP-1 therapy is recommended
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[DOI] [PubMed] [Google Scholar] 63.retmenolu O, Ssl AE, Ycel T, nerci TM, ahin A
