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Roux-en-Y gastric bypass surgery [86], sleeve gastrectomy [87] and gastrojejunostomy [88] have also been reported to improve symptoms in refractory gastroparesis, but in view of the small number of cases and the absence of controlled trials, further evaluation is required

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Changes to left atrial structure, notably left atrial enlargement, have been associated with fibrotic changes and reductions in function, including a loss of compliance [49, 50]

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The microneedle patch technology uses a biocompatible and biodegradable gelatin methacryloyl (GelMA) material that penetrates the stratum corneum (outer layer of the skin) and supports controlled release delivery and flexible drug loading capacity

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