semaglutide and restless legs Leg Syndrome: Evidence and Management Dr Nick Wilsmore - Restless

Move over Ozempic, Wegovy, Mounjaro and Zepbound Eli Lilly says another contender may be on the way

2024;2:qxae055

Unlike Wegovy or Ozempic, yerba mate does not mimic GLP-1 and should not be considered a substitute for these prescription medications

E., Amod, A., Rubio, M

Its primary physiological effects include: Glucose-dependent stimulation of insulin secretion Suppression of glucagon release Slowing of gastric emptying Promotion of satiety via central nervous system pathways GLP-1 receptors are expressed in multiple tissues, including: Pancreatic beta cells Gastric smooth muscle The hypothalamus Vagal afferent pathways Cardiovascular tissue Under normal physiology, endogenous GLP-1 has a very short half-life (approximately 12 minutes), as it is rapidly degraded by dipeptidyl peptidase-4 (DPP-4)