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Scientists found that GLP-1 receptor mRNA levels in the nucleus tractus solitarius (NTS) dropped after 1-2 weeks of treatment, matching when the drug started becoming less effective [24]

Concerns could include underdosing, lack of clinical data on microdosing, and patients making decisions without guidance, Tebra researchers concluded

Camilleri M, Malagelada J-R, Abell TL, Brown ML, Hench V, Zinsmeister AR

It is legality, pharmacy legitimacy, formulation, dosing, oversight, side effects, and whether an FDA-approved option is safer or more appropriate

[2] [3] GLP-1 medications reduced major adverse cardiovascular events by 20% in the SELECT trial, with benefits extending beyond weight loss alone