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During this time, all GLP-1RAs were approved for T2DM, and the analysis was therefore limited to comparing GLP-1RAs with other anti-diabetic medications in this population

Although the liver and the skeletal muscle do not express GIPR or GLP-1R 40,45 , and are thus not directly targeted by GLP-1GIPLani, hepatic and skeletal muscle effects are nonetheless expected, given that the molecule decreases body weight and fat mass and improve glucose metabolism, which indirectly also improve metabolism in liver and skeletal muscle

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3,9 quetiapine, false-positive methadone and TCA results, which are attributed to quetiapines resemblance in structure to methadone and TCAs

It is typically administered once per week as an injection