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69 The Trp-cage was assumed to account for the superior binding affinity of exendin-4 compared to GLP-1

Beyond weight and glucose, longterm outcomes, including cardiovascular events, are increasingly part of the evidence base

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Semaglutide Market Segmentation Analysis: By product, Ozempic held the largest share of around 60.94% in 2025, and the Wegovy segment is expected to register the highest growth By route of administration, the parenteral segment dominated the market with approximately 88.80%share in 2025, while the oral segment is expected to register the highest growth By application, type 2 diabetes mellitus accounted for the leading share of nearly 70.40% in 2025, and obesity is expected to register the highest growth Distribution channel, the retail pharmacies led the market with about 56.61% share in 2025, and online pharmacies are forecasted to grow the fastest By Product, Ozempic leads the Market, While Wegovy registers the Fastest Growth The Ozempic segment accounted for the highest revenue share of approximately 60.94% in 2025, owing to its established effectiveness in treating type 2 diabetes, its potential for reducing cardiovascular risk, and the convenience of a once-a-week dosing schedule