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This is one of the reasons it is different from GLP-1-only treatments

Endocrinol Metab (Seoul) 2016;31:258274
Exenatide was studied in Parkinsons disease : a 2017 Lancet trial showed that patients on weekly exenatide had a slight improvement in motor scores compared to placebo ( [142] )

Another medication class, DPP-4 inhibitors, works by preventing the breakdown of your body's natural GLP-1, though with more modest effects