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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP, previously known as gastric inhibitory polypeptide) are key incretin hormones secreted from the small intestine after oral intake of food

This triagonist offered additional benefits for lipid metabolism and significantly reduced plasma cholesterol and reduced markers of non-alcoholic steatohepatitis (NASH) [30]

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Subanalyses of EXSCEL, SUSTAIN-6 and PIONEER-6 trials suggested that patients with HF may not necessarily benefit from GLP-1RA therapy

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