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Patient Adherence Semaglutide can be safely used without any dose reduction in adults, geriatric patients, or in those suffering from renal and hepatic impairment

The injection site might show different reactions like bleeding, blisters, a burning sensation, or skin color changes [13]

Given the heterogeneity in study populations and the predominance of post hoc analyses, further prospective research is essential to clarify these mechanisms and to evaluate whether personalized, sex-specific approaches to GLP-1 RA therapy could improve obesity treatment outcomes

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Front Immunol 14:1244345 Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, Mele MC (2019) What is the healthy gut microbiota composition