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Retatrutide works by activating three hormone pathways involved in appetite regulation, satiety, and energy balance: GLP-1, GIP, and glucagon receptors

Footnotes Supplementary material associated with this article can be found in the online version, at doi:10.1016/j.ajpc.2023.100502

Presentations vary among individuals and can range from mild to severe

Reduced food intake means fewer minerals like sodium, potassium, and magnesiumall essential for muscle function and energy production

Furthermore, another study demonstrated that B-cell-depleted mice were only partially protected from MASH, whereas B-cell-harboring but antibody-deficient IgMi mice were fully resistant to MASH [83]