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Microbial Pathways Regulating GLP-1 As Ive discussed in other articles, as well as in my book, The Quantum Power of GLP-1 Peptides , the authors of this study frame their exploration by first establishing the four principal microbial metabolite pathways that drive GLP-1 secretion from intestinal L cells, including SCFAs (acetate, propionate, butyrate) produced by bacteria such as Faecalibacterium prausnitzii , Roseburia intestinalis , Akkermansia muciniphila , and Bifidobacterium activate GPR41 and GPR43 receptors on L cells, triggering calcium influx and GLP-1 exocytosis