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La FDA aprob una forma de semaglutida para el control del peso crnico en 2021

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Also, a small cross-sectional study of 36 women with PCOS noted no changes in depression scores associated with liraglutide use over 6 months 204 , while another reported worsening depressive symptoms, which correlated with higher perceived stress scores, in 43 exenatide users with diabetes and obesity against non-users at 3 months 205

These central effects translate into substantial weight loss - typically 5%-15% of body weight with current GLP-1 RAs - which directly ameliorates hepatic steatosis by reducing adipose tissue mass, reducing hepatic free fatty acid influx, and improving insulin sensitivity

Although superiority for the primary endpoint was not demonstrated against dulaglutide, the consistently favorable cardiometabolic risk-factor shifts suggest a potentially favorable cardiovascular profile (8)