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In obesity, elevated leptin levels promote Th1 and Th17 polarization, impair regulatory T-cell function, and enhance autoreactive immune responses, while hypoadiponectinemia removes a key anti-inflammatory brake [34,35]

These data suggested that berberine ameliorates diabetic conditions in db/db mice

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The type 2 diabetes mellitus sector stands out as the dominant player, holding the largest revenue share of 62.3% in the GLP-1 receptor agonist market

doi: 10.1016/j.clinthera.2014.11.008 [DOI] [PubMed] [Google Scholar] 5
