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Semaglutide is a glucagon-like peptide-1 receptor agonist which has been shown to reduce body weight and improve health status in patients with obesity related heart failure with preserved ejection fraction in the STEP-HFpEF Program [1]

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Unlike the current widely used medications such as Ozempic and Mounjaro that target the GLP-1 pathway alone, retatrutide, known as a GLP-3, targets three pathways related to metabolism: GIP, GLP-1, and glucagon

While these findings suggest semaglutides efficacy in cardiorenal diseases, gaps in evidence remain, including the need for event-driven trials in HF populations without ASCVD and irrespective of obesity

Find out more about Ozempic in todays deep dive: What is the Ozempic Dosage for Weight Loss?