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According to Folek, obesity experts arent really sure how topiramate curbs hunger, but they think it works on brain chemicals to restrict the release of glutamate, another neurotransmitter that plays a role in appetite

Structural figures were prepared in UCSF Chimera 1.17.3, UCSF ChimeraX v1.0 and PyMOL 2.5.8 ( The final refinement statistics are provided in Table S1

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