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Unfortunately, its effectiveness can be limited particularly during tumor recurrence by its toxicity to renal proximal tubule cells (reviewed in Zhang and Hanigan, 2003)

IJMS 22(15):8161 Wu J, Wang K, Wang X, Pang Y, Jiang C (2021) The role of the gut microbiome and its metabolites in metabolic diseases

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In fatty liver disease, accumulated fat triggers inflammatory pathways and increases free radical production within liver cells

(28) The study included 1,222,436 patients with type 2 diabetes who were newly prescribed SGLT-2 inhibitors, GLP-1 agonists, DPP4-Is, or older antidiabetic agents (metformin, sulfonylureas, alpha glucosidase inhibitors, thiazolidinediones), with patients categorized based on their first recorded prescription