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The activation of RBOH proteins on the plasma membrane generates superoxide radicals in the apoplast, which are converted to H 2 O 2 , through either spontaneous dismutation or the action of SOD

This can range from a simple break in the epithelial integrity of the skin or it can be deeper, extending into subcutaneous tissue with damage to other structures such as tendons, muscles, vessels, nerves, parenchymal organs, and bones [12, 13]

Subacute combined degeneration of the spinal cord

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Targeting the TGF pathway for cancer therapy