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The pattern C/M patch demonstrated improved cardiac functions, decreased cardiac hypertrophy and fibrosis, enhanced migration from the patch to the infarcted area, as well as the formation of new muscle tissue and capillaries, leading to overall improvements in cardiac function

Several patents are available for drug delivery via the nasal route to either directly target the CNS, or by systemic transport of the drugs by the nasal route to target the CNS

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[188] [189] One known example of differences in signal transduction is between the two 5-HT 2A agonists serotonin and DOI that involves differential recruitment of intracellular proteins called -arrestins, more specifically arrestin beta 2

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