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In human umbilical vein endothelial cells (HUVECs) and aortas from ApoE -/- mice, TMAO increased the concentrations of reactive oxygen species (ROS), especially superoxide, by inhibiting the SIRT3-SOD2-mitochondrial ROS signaling pathway (75)

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All procedures were in accordance with the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and took into account the 3R principles

This compound can be used as a tracer 2

Both deficiency and excess of iron can cause significant disruptions in bodily functions [24]