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The data revealed a significant increase in the proportion of CXCL9 + macrophages and a notable reduction in the SPP1 + macrophages fraction in response to chemoimmunotherapy

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[DOI] [PubMed] [Google Scholar] 86.Al-Rooqi M.M., Mughal E.U., Raja Q.A., Hussein E.M., Naeem N., Sadiq A., Asghar B.H., Moussa Z., Ahmed S.A

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While refrigeration can't stop this, the overall slowdown of chemical reactions helps mitigate the damage
