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These pleiotropic effects likely contribute to the cardioprotective and cognitive-preserving actions of SGLT2 inhibitors, further supporting the concept that targeting mitochondrial dysfunction can concurrently benefit cardiovascular and neurological outcomes

In one study of nearly 38,000 elderly men who were dementia-free at the beginning of the study, those with hearing loss had a 69% higher risk of developing dementia during an average of 11.1 years of follow-up

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