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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Slavin J.L., Lloyd B

However, the levels of glutathione can reduce due to age, high blood sugar levels, excessive alcohol use, excessive exercise, exposure to toxins, and illness

The lactate shuttle hypothesis further revealed its pivotal roles in oxidative substrate transport and cellular signaling via monocarboxylate transporters (MCTs), leading to its recognition as a potent signaling metabolite, particularly through its receptor GPR81 (6-8)

[98] Kumar NB, Pow-Sang J, Spiess P, et al

Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2