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The upstream regulation of GPX4 mainly include transcription factors such as Nrf2 (Dodson et al., 2019), MYB (Hao et al., 2017), Tfap2c (Alim et al., 2019), Sp1 (Alim et al., 2019), Lipocalin 2 (LCN2) (Chaudhary et al., 2021), mTORC1 (Saxton and Sabatini, 2017

Once the ubiquitin chain reaches four ubiquitins in length, the polyubiquitinated protein becomes a new substrate for degradation by the 26S proteasome (67)

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