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This localization is directly related to the key role of Tau in the maintenance of the complex architecture of the neuron by stabilization of microtubule (MT) bundles through interactions with tubulin subunits (Avila et al., 2004)

Here is a dedicated chart for sub-standard doses at a 5mg/mL concentration, which provides better measurement accuracy for smaller amounts
However, the SPH domain lacks proteolytic activity due to a mutation of the catalytic residues
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You know the exact milligrams you receive each visit
